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Page 1
Vanilloids induce oral cancer apoptosis independent of TRPV1.
Gonzales CB, Kirma NB, De La Chapa JJ, Chen R, Henry MA, Luo S, Hargreaves KM. Gonzales CB, et al. Among authors: de la chapa jj. Oral Oncol. 2014 May;50(5):437-47. doi: 10.1016/j.oraloncology.2013.12.023. Epub 2014 Jan 14. Oral Oncol. 2014. PMID: 24434067 Free PMC article.
Co-targeting ALK and EGFR parallel signaling in oral squamous cell carcinoma.
Gonzales CB, De La Chapa JJ, Saikumar P, Singha PK, Dybdal-Hargreaves NF, Chavez J, Horning AM, Parra J, Kirma NB. Gonzales CB, et al. Among authors: de la chapa jj. Oral Oncol. 2016 Aug;59:12-19. doi: 10.1016/j.oraloncology.2016.05.007. Oral Oncol. 2016. PMID: 27424178 Free PMC article.
Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells.
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Dasari R, et al. Among authors: de la chapa jj. ChemMedChem. 2015 Dec;10(12):2014-26. doi: 10.1002/cmdc.201500360. Epub 2015 Oct 5. ChemMedChem. 2015. PMID: 26434977 Free PMC article.
The novel capsazepine analog, CIDD-99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1-independent induction of ER stress, mitochondrial dysfunction, and apoptosis.
De La Chapa JJ, Singha PK, Self KK, Sallaway ML, McHardy SF, Hart MJ, McGuff HS, Valdez MC, Ruiz F 2nd, Polusani SR, Gonzales CB. De La Chapa JJ, et al. J Oral Pathol Med. 2019 May;48(5):389-399. doi: 10.1111/jop.12843. Epub 2019 Apr 4. J Oral Pathol Med. 2019. PMID: 30825343 Free PMC article.
Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines.
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Dasari R, et al. Among authors: de la chapa jj. Eur J Med Chem. 2015 Oct 20;103:226-37. doi: 10.1016/j.ejmech.2015.08.047. Epub 2015 Aug 29. Eur J Med Chem. 2015. PMID: 26360047 Free PMC article.